Jean Spénard Selected Research

2- methyl- 3- (2- ((4- nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester

1/2011	NCX 1000 Alone or in Combination with Vitamin E Reverses Experimental Nonalcoholic Steatohepatitis in the Rat Similarly to UDCA.
5/2010	NCX-1000, a nitric oxide-releasing derivative of UDCA, does not decrease portal pressure in patients with cirrhosis: results of a randomized, double-blind, dose-escalating study.

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Jean Spénard Research Topics

Disease

2	Non-alcoholic Fatty Liver Disease 05/2011 - 01/2011
2	Fibrosis (Cirrhosis) 05/2011 - 05/2010
2	Infections 10/2005 - 03/2003
1	Insulin Resistance 05/2011
1	Inflammation (Inflammations) 05/2011
1	Proctitis 11/2010
1	Portal Hypertension 05/2010
1	Exocrine Pancreatic Insufficiency 01/2010
1	Cystic Fibrosis (Mucoviscidosis) 01/2010
1	Necrosis 02/2007
1	Neoplasms (Cancer) 01/2006
1	Ulcerative Colitis 01/2005
1	Duodenal Ulcer (Curling's Ulcer) 03/2003

Drug/Important Bio-Agent (IBA)

2	2- methyl- 3- (2- ((4- nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid esterIBA 01/2011 - 05/2010
2	Mesalamine (Mesalazine)FDA LinkGeneric 11/2010 - 01/2005
2	Capsules (Microcapsules)IBA 10/2005 - 03/2003
1	Biomarkers (Surrogate Marker)IBA 05/2011
1	Transaminases (Aminotransferases)IBA 05/2011
1	AcidsIBA 05/2011
1	Vitamin E FDA LinkGeneric 01/2011
1	Suppositories (Vaginal Suppositories)IBA 11/2010
1	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 05/2010
1	Benzoic Acid (Potassium Benzoate)FDA Link 05/2010
1	EstersIBA 05/2010
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2010
1	Pancrelipase (Creon)FDA Link 01/2010
1	Superoxides (Superoxide)IBA 02/2007
1	Malondialdehyde (Propanedial)IBA 02/2007
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2006
1	Dihematoporphyrin Ether (Porfimer Sodium)FDA Link 01/2006
1	Omeprazole (Prilosec)FDA LinkGeneric 03/2003
1	Clarithromycin (Biaxin)FDA LinkGeneric 03/2003
1	Amoxicillin (Wymox)FDA LinkGeneric 03/2003
1	Metronidazole (Metric)FDA LinkGeneric 03/2003
1	BismuthIBA 03/2003
1	Tetracycline (Achromycin)FDA LinkGeneric 03/2003

Therapy/Procedure

1	Glycemic Control 05/2011
1	Enzyme Replacement Therapy 01/2010
1	Photochemotherapy (Photodynamic Therapy) 01/2006
1	Therapeutics 03/2003